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Sanofi and Regeneron opened their update on the cancer drug Zaltrap (aflibercept) on a sweet note: the FDA has granted a priority review of their new drug application for colorectal cancer. but the news wrapped a bitter pill, as they quickly went on to acknowledge that their cancer contender had failed a late-stage study for prostate cancer.

The Phase III Venice study involving patients with metastatic, androgen dependent prostate cancer "did not meet the pre-specified criterion of improvement in overall survival," the companies reported. No data was put out in the release and investigators noted that they would review the results at a later scientific meeting.

Last fall, as analysts were growing increasingly skeptical about Sanofi ($SNY) CEO Chris Viehbacher's (photo) promise for better results from the pharma giant's restructured R&D operation, the company listed Zaltrap as one of its top late-stage prospects in the pipeline. Today's mixed news may not help much in making its case for a turnaround, but the primary focus in R&D has long been on the positive colorectal cancer results seen in Phase III. and that's the note Sanofi was trying to stay focused on today.  

"Sanofi and Regeneron are committed to the continued development of Zaltrap and we are very pleased that the FDA has chosen to grant priority review to Zaltrap in metastatic colorectal cancer," said Debasish Roychowdhury, who heads up Sanofi's cancer drug work. "we look forward to working closely with the FDA to potentially bring an important new option to patients with this difficult disease."

The target date for their application on colon cancer is August 4. 

- get the press release – here's the Reuters story

Related Article: Sanofi, Regeneron buoyed by PhIII colon cancer success for aflibercept

The Bruins [team stats] put the finishing touches on the regular season yesterday with an entertaining 4-3 comeback win in a shootout over the Buffalo Sabres.

In the 82-game grind, there were the nervous moments of the 3-7 October. there were shades of the high-flying Bruins of the 1970s with a 21-2-1 run in November and December. Then there was the very worrisome two-month stretch of sub-.500 hockey before they finally finished up strong.

Now all those wild fluctuations are in the rear-view mirror. and the real defense of the Stanley Cup begins for the Bruins

“the regular season is over, thank God,” Shawn Thornton said. “Let’s get ready for the fun stuff.”

After dispatching the Sabres, the B’s needed to wait until about 10 p.m. to find out their opponent in the first round of the playoffs: the Washington Capitals.

The Ottawa Senators had begun the day as the B’s most likely foe, but the Sens’ loss to New Jersey and Washington’s win over the New York Rangers vaulted the Caps into the No. 7 seed and earned a date with the Bruins. (Washington also had a shot to win the Southeast Division, but Florida quashed those hopes by beating Carolina to secure the No. 3 seed.)

The B’s finished the season with a 5-1-0 record against Ottawa and were 1-2-1 vs. Washington. If they had wanted to, the B’s could have made the Sens their opponent by letting them get a point in their game against Ottawa on Thursday. but though they rested their stars, the B’s beat Ottawa, 3-1.

After the win yesterday, coach Claude Julien said his team wasn’t about to try to cherry-pick its opponent.

“anybody who decides who they want as an opponent, saying, ‘I’d rather play this team than that team,’ or plays to pick their own opponent doesn’t deserve to win,” Julien said. “this is a game. this is not wrestling, it’s not a fake sport. you don’t go out there and pretend to play and make sure you lose because there’s a certain team you want to play against. because karma is a pretty powerful thing. and I believe in doing things right. If we’re going to win, we’re going to have to beat every team that comes in our way.”

The B’s certainly took that approach yesterday in a game that meant nothing for them or the Sabres, who were knocked out of the playoffs Thursday.

At 8:46 of the third period, the B’s found themselves down 3-1 after a Jason Pominville goal, and it would have been easy to pack it in at that point. They did the opposite. For the second time in the game, Patrice Bergeron set up Tyler Seguin at 9:56 for his team-leading 29th goal. Seguin, 20, also became the youngest player to lead the B’s in scoring (67 points).

Just 2:25 later, Bergeron made a steal and dished it down to linemate Brad Marchand, who beat Jhonas Enroth for his 28th goal of the season.

Bergeron had three assists on the night and finished the season atop the league with a plus-36 rating. but he wasn’t done. with the game still to be won, Bergeron was the only player to score in the shootout, slipping a crafty little shot between Enroth’s pads. Tim Thomas [stats] stopped Tyler Ennis, Brad Boyes and Pominville to seal the victory and a 102-point season.

“(Bergeron) shows up every day with a purpose,” Julien said. “If it’s a practice, he’ll be the best practice player. If it’s a game, he wants to be the best player in the game. and today was no exception.”

Now, the Bruins’ season may not be over for a couple of months. It could be done in a couple of weeks, too. but after the B’s fought through the midseason mental fatigue and finished the season 9-2-1, Julien feels his team is ready to do battle.

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By Daily Mail Reporter

PUBLISHED: 14:53 EST, 25 March 2012 | UPDATED: 14:06 EST, 26 March 2012

In today’s $60billion diet industry, it’s hard to stand out from the fierce competition but these nostalgic adverts appear to have the secret – just make some incredibly outrageous promises to the despairing dieter.

The products on these vintage posters offer a range of solutions to shift those extra pounds – from the electric spot reducer which guaranteed to jiggle away excess bulk to soap which would ‘melt’ fat while you bathed.

Few gimmicks have stood the test of time but companies like WeightWatchers which promote balanced diet and exercise are still going strong.

Creating a buzz: The Spot Reducer ‘guarantees’ to target problem areas of weight gain by jiggling the fat away with its unique scientific method in 1955

Money down the drain: La Mar Reducing Soap from the 1920s promised to ‘wash away fat and years of age’ to the gullible consumer

Obesity and its related diseases have now reached epidemic proportions in the U.S. More than a third of American adults (35.7 per cent) are obese along with 17 per cent (or 12.5 million) children and teenagers.

In 12 states – Alabama, Arkansas, Kentucky, Louisiana, Michigan, Mississippi, Missouri, Oklahoma, South Carolina, Tennessee, Texas and West Virginia – around 40 per cent of people are obese.

The U.S. diet market was valued at $59.7 billion in 2010. Due to the prevalence of America’s weight problems, the Food & Drug Administration has been approving more new obesity drugs. Phentermine, an appetite suppressant, is the most commonly prescribed diet pill, accounting for half of the market.

Breakfast club: The campaign for Kellogg’s All-Bran in 1933 promoted a healthy diet for weight loss over a quick fix

Pulling no punches: this poster for Professor F.J. Kellogg’s weight loss remedy gets straight to the point

Snack attack: Black and white magazine advert for Ryebisk slimming biscuits from around 1928 promised ‘a slim silhouette’

Effective: WeightWatchers is one of the few solutions for being overweight that has stood the test of time and takes a large chunk of American’s $60 billion diet industry

Shedding the pounds: The Slimmers Glove system told dieters in 1975 that all they need to lose fatty deposits is a good old scrub in the tub

When diet and exercise just don't give people the desired effects, some try out diet pills. and why not? Their promise of swallowing a pill in order to shed the pounds sounds like a great deal. Dr. Marc Siegel stopped by Fox and Friends to discuss the pros and cons of weight loss pills. He… Read More.
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See How to Lose Belly fat at: http://www.plentyofhealth.com/2011/10/19/perform -the-right-type …
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March 20, 2012 at 2:24 pm Leave a comment

Exclusive by Elie Wiesel: the Tragedy in ToulouseThe Algemeiner March 20, 2012

Will the hatred of the Jews ever finally vanish? Will Jewish children always be in danger?

This time, a murderer slew four Jews: a teacher and three young children.

When a blood-thirsty Jew-hater wants to kill Jews, he goes first to the Jewish schools. Jewish children are his primary target.

It’s always been this way. this is what Pharaoh, King of Egypt did, what Hitler did. and this is what happened now.

This is the background to the tragedy that occurred in the French city, Toulouse.

I have visited that city many times. the Jewish community there is old and well-established – it dates back to the Middle Ages – but it is dynamic.

In the streets, you can see Jews wearing yarmulkas. nobody thinks of anti-Semitism. Spiritually, it is one of richest Jewish communities in France.

Obviously, the terrible murderous attack evoked tears and rage among both Jews and non-Jews. the President, his ministers, and other political figures in France, as well as all the newspapers, have demanded that the murderer be found and punished.

It often happens like this. Jewish blood is spilled and, temporarily, sympathy for Jews grows; the world warms to them.

But the pain does not go away, nor does the anger. we think about the martyrs: Rabbi Yochanan Sandler, his sons Aryeh and Gavriel, and Miriam Monsonego. we say, as is Jewish tradition: “May G-d avenge their blood.” That will be the response from Above.

Our own answer must be concrete and to the point. when we are persecuted, our response must be: we will remain Jewish – and do everything to become more Jewish.

“we stand in solidarity with our brothers and sisters in France”—Rabbi Marvin Hier

Yesterday’s murder of a father and two of his children along with the daughter of the principal of the Jewish day school in Toulouse, France was the worst anti-Semitic attack in France in the last 30 years.

“the brutality of this attack in broad daylight indicates the murderers’ deep hatred for Jews. this is a wake-up call, not only for the Jews of France, but for Jews everywhere to be vigilant.

The Simon Wiesenthal Center joins with the House of Israel and people of consciousness everywhere in condemning this horrific act of inhumanity,” said Rabbi Marvin Hier, SWC Dean and Founder.

Paris-based SWC International Relations Director, Dr. Shimon Samuels, is closely monitoring developments in France as authorities strive to identify the perpetrators and apprehend all those involved in this heinous crime. In light of the incessant anti-Israel and anti-Semitic rhetoric worldwide, the Center urges all Jewish institutions to review their security procedures in conjunction with local law enforcement.

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Watching the draft can be a daunting task for the uninitiated because many of the NFL Network commentators use a language that rivals the geek speak of your typical ComicCon (and I can say that seeing how I watch every minute of the draft and spend a considerable amount of time at the San Diego ComicCon every year.)

With that in mind, allow me to offer you an NFL draft glossary to help you understand what these guys are talking about this April.

————————————————————————————————————————————–

Best player available—————————————————————————————————————————————

What you think it means: We want to draft the best player available.what it actually means: We have no idea what we’re doing and we’re just winging it now.

—————————————————————————————————————————————Cabin fever—————————————————————————————————————————————

What you think it means: a quarterback who flees the pocket too early.what it actually means: How Vikings fans feel watching a football game in the Metrodome.

—————————————————————————————————————————————Falling stock—————————————————————————————————————————————what you think it means: a once-highly regarded player is falling down draft boards.what is actually means: he would be perfect for the Raiders.

—————————————————————————————————————————————Good punch—————————————————————————————————————————————what you think it means: a lineman who gets good extensions with his arm while blocking.what it doesn’t mean: Legarrette Blount’s initial scouting report.

—————————————————————————————————————————————Hands like feet—————————————————————————————————————————————what you think it means: bad hands.what it actually means: Go play soccer.

—————————————————————————————————————————————Jitterbug runner—————————————————————————————————————————————what you think it means: a shifty running back.what it actually means: Player most likely to appear on “Dancing with the Stars.”

—————————————————————————————————————————————One-trick pony—————————————————————————————————————————————what you think it means: a guy who is only good at one thing.what it actually means: Tim Tebow.

—————————————————————————————————————————————Possession guy—————————————————————————————————————————————what you think it means: a receiver with great hands.what it actually means: slow.

—————————————————————————————————————————————Rising stock—————————————————————————————————————————————what you think it means: He’s gaining in popularity among scouts and GMs.what it actually means: good job not screwing up, kid.

—————————————————————————————————————————————Seeing ghosts—————————————————————————————————————————————what you think it means: a quarterback who gets sacked a lot.what it actually means: what happens to Tony Romo every time the playoffs start. Just kidding, Tony. This is what happens to him in December.

—————————————————————————————————————————————This guy has character issues—————————————————————————————————————————————what you think it means: Issues from the players past are coming back to haunt him now.what it actually means: he would be perfect for the Lions.

—————————————————————————————————————————————Throwing from all platforms—————————————————————————————————————————————what you think it means: a quarterback can throw from many different angles.what it actually means: a quarterback who can tweet, text and perform well on TV.

—————————————————————————————————————————————We’ll look to upgrade all positions—————————————————————————————————————————————what you think it means: the team is looking to upgrade all positions.what it actually means: our players stink.

You can follow Adam Rank via Twitter or via Facebook. also be sure to catch the latest “Dave Dameshek Football Program.”

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KANSAS CITY, Mo. — the success of the Chiefs’ draft will ultimately be judged sometime down the road. In the meantime, general manager Scott Pioli has a few things he will use to measure it by.

One of them this year and every year is that the Chiefs use one of their picks on a quarterback.

“every year if possible we’d like to find a way to draft a quarterback because it’s just good business and it’s smart business,” Pioli said Monday. “Now, who that is and when we do it and how we do it, you never know.”

The first of the Chiefs’ eight picks this year will come 11th in the first round. there, the player generally regarded as the third-best quarterback in the draft, Ryan Tannehill of Texas A&M, could be available to them.

The Chiefs have spent significant time investigating Tannehill, who spent the first half of his collegiate career as a wide receiver and started just 19 games at quarterback. they met with him at the NFL scouting combine, worked him out at Texas A&M and had him in to Kansas City for a visit.

None of which, of course, means the Chiefs will draft Tannehill if he slides to them at that 11th pick.

“I’m not going to get into all the specifics of a player,” Pioli said when asked about Tannehill. “but I know this: I know he’s a competitive, young player, a smart player, a tough player. He’s a guy I have a lot of respect for.”

Whether it’s Tannehill or a lesser prospect taken later in the draft, Pioli would like the Chiefs to find another quarterback to go with the three they already have: starter Matt Cassel, Brady Quinn and Ricky Stanzi.

The Chiefs have sent mixed signals on Cassel during the offseason. Both Pioli and coach Romeo Crennel were less than enthusiastic in their support of Cassel on Monday.

Pioli: “we like Matt Cassel, and we think Matt Cassel is a good quarterback.”

Crennel: “Matt has proven he can get a team to the playoffs. Now it’s up to us to get him to do it again.”

If the Chiefs are eventually in a spot where they have to make a decision on Tannehill, the key factor could be what they think about Cassel’s long-term prospects. it may be years before they again will be in position to draft a so-called franchise quarterback.

“I think the numbers say that 50 percent of first-round quarterbacks don’t make it,” Crennel said. “Now, if you said you’ve got a 50-percent chance of the guy you pick making it, you wouldn’t feel all that good about it. but the quarterback is a position that you have to have.”

During his time as personnel director for the Patriots and general manager with the Chiefs, Pioli has largely been associated with two starting quarterbacks — Tom Brady with New England and Cassel in Kansas City.

It’s worth noting that both players entered the NFL as low-round draft picks. Brady was chosen in the sixth round in 2000 by the Patriots and Cassel in the seventh round in 2005, also by New England.

The Chiefs have selected one quarterback in three drafts with Pioli as their general manager, taking Stanzi in the fifth round last year.

So, using history as a guide, the Chiefs will find their 2012 rookie quarterback in a later round.

“Quarterback is a really difficult position to play in this league,” Pioli said. “This league’s history shows there are a number of quarterbacks that have played in this league … that given time to physically develop, emotionally develop, they become good players in this league. the other thing is if you get a good player at that position and you develop him and you are (otherwise) set at that position, you can (trade) that player and they have a lot of value around the league as long as you pick the right one. I’ve been a part of teams where we’ve picked the wrong ones and we’ve picked the right ones.”

The Chiefs, and other NFL teams, are still waiting to hear from the league how many players they will be allowed to bring to training camp. the number will be somewhere between 80, where it’s been the last few years, and 90.

“That’s going to have a lot to do with how many people we take (to camp) at any position, quarterback being one of them,” Pioli said. “Ideally, and we talked about it, we’d love to have four quarterbacks going into training camp. but you don’t want too many quarterbacks because if you’re going to develop players or even have them compete against one another, there are only so many balls that can be thrown in practice.”